翻訳と辞書 Words near each other ・ Proton Saga (first generation) ・ Proton Saga (second generation) ・ Proton satellite ・ Proton Satria ・ Proton Satria R3 ・ Proton Savvy ・ Proton spin crisis ・ Proton Suprima S ・ Proton Synchrotron ・ Proton Synchrotron Booster ・ Proton therapy ・ Proton Tiara ・ Proton Waja ・ Proton Wira ・ Proton-coupled electron transfer ・ Proton-coupled folate transporter ・ Proton-dependent oligopeptide transporter ・ Proton-enhanced nuclear induction spectroscopy ・ Proton-gated urea channel ・ Proton-K ・ Proton-M ・ Proton-PM ・ Proton-pump inhibitor ・ Proton-pumping pyrophosphatase ・ Proton-sensing G protein-coupled receptors ・ Proton-to-electron mass ratio ・ Proton-transfer-reaction mass spectrometry ・ Proton200k ・ Protonaegleria ・ Protonarthrini Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Proton-coupled folate transporter ： ウィキペディア英語版 Proton-coupled folate transporter The proton-coupled folate transporter (PCFT) is a member (SLC46A1) of the superfamily of solute transporters. The major physiological roles of PCFT are in mediating the intestinal absorption of folates, required to meet mammalian requirements for the B9 folate vitamins, and the delivery of folates to the central nervous system. ==Structure== PCFT is located on chromosome 17q11.2 and consists of five exons encoding a protein with 459 amino acids and a MW of ~50kDa. PCFT is highly conserved, sharing 87% identity to the mouse and rat PCFT and retaining more than 50% amino acid identity to the frog (XP415815) and zebrafish (AAH77859) proteins. Structurally, there are twelve transmembrane helices with the N- and C- termini directed to the cytoplasm and a large internal loop that divides the molecule in half. There are two glycosylation sites (N58, N68) and a disulfide bond connecting residues C66, in the 1st and C298 in the 4th, external loop. Neither glycosylation nor the disulfide bond are essential for function.〔 Residues have been identified that play a role in proton-coupling, proton binding, folate binding and oscillation of the carrier between its conformational states. PCFT forms oligomers and some of the linking residues have been identified. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Proton-coupled folate transporter」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.